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Penn Bioinformatics Forum – Tandy Warnow, PhD

February 13, 2019 @ 3:00 pm - 4:30 pm

Tandy Warnow, PhD
Professor of Computer Science, Bioengineering
University of Illinois

Improving Bioinformatics Analyses using Ensembles of Hidden Markov Models

Profile Hidden Markov Models (HMMs) are statistical models that are in wide use in bioinformatics. In this talk I will present a novel way of using HMMs that improves many bioinformatics analyses. The key approach is to represent a multiple sequence alignment using a collection of profile HMMs, and then use this complex model to analyze new sequences. As I will show, this approach improves accuracy and scalability of multiple sequence alignments,  protein classification, phylogenetic placement, and taxon identification of environmental samples in microbiome analysis.

Reception to follow.


February 13, 2019
3:00 pm - 4:30 pm
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BRB Auditorium
421 Curie Blvd
Philadelphia, PA 19104 United States
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