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Penn Bioinformatics Forum – Tandy Warnow, PhD
February 13, 2019 @ 3:00 pm - 4:30 pm
Tandy Warnow, PhD
Professor of Computer Science, Bioengineering
University of Illinois
Improving Bioinformatics Analyses using Ensembles of Hidden Markov Models
Profile Hidden Markov Models (HMMs) are statistical models that are in wide use in bioinformatics. In this talk I will present a novel way of using HMMs that improves many bioinformatics analyses. The key approach is to represent a multiple sequence alignment using a collection of profile HMMs, and then use this complex model to analyze new sequences. As I will show, this approach improves accuracy and scalability of multiple sequence alignments, protein classification, phylogenetic placement, and taxon identification of environmental samples in microbiome analysis.
Reception to follow.